

| Каталожный номер | HB840014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-NPPB Polyclonal Antibody (HB840014) is a rabbit polyclonal antibody detecting NPPB in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NPPB (His27-Arg102). | ||||||||
| Цель | NT-proBNP(1-76), preproBNP, BNP(1-32), BNP(4-32), proBNP, Brain natriuretic peptide, BNP, des-SerPro-BNP, NPPB, NT-pro-BNP, proBNP(79-108), Iso-ANP, Natriuretic peptides B, Gamma-brain natriuretic peptide, Brain natriuretic factor prohormone, BNP-32 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P16860 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. 1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777 2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040 3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098 4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824 5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887 6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034 7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504 | ||||||||
| Примечание | For research use only. |




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