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| カタログ番号 | HY501014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NPS Polyclonal Antibody (HY501014) is a rabbit polyclonal antibody detecting NPS in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NPS (Ser29-Lys88). | ||||||||
| ターゲット | NPS, Neuropeptide S | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0C0P6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neuropeptide S (NPS) is a ~10 kDa protein. Ligand for NPSR1. Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. 1. Xu, YL. et al. (2004) Neuron 43, 487-97. PMID: 15312648 2. Vendelin, J. et al. (2005) American journal of respiratory cell and molecular biology 33, 262-70. PMID: 15947423 3. Roth, AL. et al. (2006) The Journal of biological chemistry 281, 20809-20816. PMID: 16720571 4. Bernier, V. et al. (2006) The Journal of biological chemistry 281, 24704-12. PMID: 16790440 5. Erdmann, F. et al. (2015) PloS one 10, e0117319. PMID: 25714705 6. Liao, Y. et al. (2016) The Journal of biological chemistry 291, 7505-16. PMID: 26865629 | ||||||||
| 注意事項 | For research use only. |
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