Anti-NR1H2/LXRb Polyclonal Antibody (HX964014)

Name: Anti-NR1H2/LXRb Polyclonal Antibody
Brand: abinScience
SKU: HX964014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HX964014

説明

Anti-NR1H2/LXRb Polyclonal Antibody (HX964014) is a rabbit polyclonal antibody detecting NR1H2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human NR1H2/LXRb (Lys72-Glu460).

ターゲット

UNR, Oxysterols receptor LXR-beta, LXRB, NR1H2, Nuclear receptor subfamily 1 group H member 2, Liver X receptor beta, NER, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER

精製

Purified by antigen affinity column.

アクセッション番号

P55055

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Oxysterols receptor LXR-beta (NR1H2/LXRb) is a ~50 kDa protein. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis.

1. Sakurabashi, A. et al. (2015) The Journal of steroid biochemistry and molecular biology 149, 80-8. PMID: 25661920

2. Venteclef, N. et al. (2010) Genes & development 24, 381-95. PMID: 20159957

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-NR1H2/LXRb Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-NR1H2/LXRb Polyclonal Antibody (HX964014)

概要

イメージ

参考文献

データシート

SDS