

| Каталожный номер | HV836014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-NR1H4/FXR Polyclonal Antibody (HV836014) is a rabbit polyclonal antibody detecting NR1H4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NR1H4/FXR (Leu211-Gln486). | ||||||||
| Цель | Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, RXR-interacting protein 14, BAR, FXR, Bile acid receptor, NR1H4, RIP14, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q96RI1 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Bile acid receptor (NR1H4/FXR) is a ~55 kDa protein. Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. 1. Makishima, M. et al. (1999) Science (New York, N.Y.) 284, 1362-5. PMID: 10334992 2. Parks, DJ. et al. (1999) Science (New York, N.Y.) 284, 1365-8. PMID: 10334993 3. Modica, S. et al. (2010) Nuclear receptor signaling 8, e005. PMID: 21383957 4. Hollman, DA. et al. (2012) Biochimica et biophysica acta 1821, 1443-52. PMID: 22820415 5. Pircher, PC. et al. (2003) The Journal of biological chemistry 278, 27703-11. PMID: 12754200 6. Ananthanarayanan, M. et al. (2004) The Journal of biological chemistry 279, 54348-57. PMID: 15471871 7. Sanyal, S. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 15665-70. PMID: 17895379 8. Grober, J. et al. (1999) The Journal of biological chemistry 274, 29749-54. PMID: 10514450 9. Neimark, E. et al. (2004) Hepatology (Baltimore, Md.) 40, 149-56. PMID: 15239098 10. Landrier, JF. et al. (2006) American journal of physiology. Gastrointestinal and liver physiology 290, G476-85. PMID: 16269519 | ||||||||
| Примечание | For research use only. |
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