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| カタログ番号 | HC621014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NSUN2 Polyclonal Antibody (HC621014) is a rabbit polyclonal antibody detecting NSUN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NSUN2 (His415-Arg767). | ||||||||
| ターゲット | Misu, NSUN2, hTrm4, RNA cytosine C(5)-methyltransferase NSUN2, TRM4, NOL1/NOP2/Sun domain family member 2, tRNA methyltransferase 4 homolog, mRNA cytosine C(5)-methyltransferase, SAKI, Substrate of AIM1/Aurora kinase B, Myc-induced SUN domain-containing protein, tRNA cytosine C(5)-methyltransferase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q08J23 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RNA cytosine C(5)-methyltransferase NSUN2 is a ~86 kDa protein. RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. 1. Brzezicha, B. et al. (2006) Nucleic acids research 34, 6034-43. PMID: 17071714 2. Auxilien, S. et al. (2012) RNA biology 9, 1331-8. PMID: 22995836 3. Gkatza, NA. et al. (2019) PLoS biology 17, e3000297. PMID: 31199786 4. Chen, X. et al. (2019) Nature cell biology 21, 978-990. PMID: 31358969 5. Van Haute, L. et al. (2019) Nucleic acids research 47, 8720-8733. PMID: 31276587 9. Hussain, S. et al. (2013) Cell reports 4, 255-61. PMID: 23871666 | ||||||||
| 注意事項 | For research use only. |
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