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| カタログ番号 | HV235014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NUP85 Polyclonal Antibody (HV235014) is a rabbit polyclonal antibody detecting NUP85 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NUP85 (Arg130-Leu368). | ||||||||
| ターゲット | Pericentrin-1, Nucleoporin Nup85, Nucleoporin Nup75, PCNT1, 85 kDa nucleoporin, NUP75, NUP85, Nuclear pore complex protein Nup85, FROUNT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BW27 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nuclear pore complex protein Nup85 is a ~75 kDa protein. Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. 1. Harel, A. et al. (2003) Molecular cell 11, 853-64. PMID: 12718872 2. Orjalo, AV. et al. (2006) Molecular biology of the cell 17, 3806-18. PMID: 16807356 3. Terashima, Y. et al. (2005) Nature immunology 6, 827-35. PMID: 15995708 4. Braun, DA. et al. (2018) The Journal of clinical investigation 128, 4313-4328. PMID: 30179222 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-NUP85 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: HT-29 cell lysate
Lane 3: LO2 cell lysate
Lane 4: 293T cell lysate
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