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| カタログ番号 | HF612014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-OAS1 Polyclonal Antibody (HF612014) is a rabbit polyclonal antibody detecting OAS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OAS1 (Ser74-Pro165). | ||||||||
| ターゲット | E18/E16, (2-5')oligo(A) synthase 1, 2-5A synthase 1, 2'-5'-oligoadenylate synthase 1, OAS1, OIAS, p46/p42 OAS | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P00973 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 2'-5'-oligoadenylate synthase 1 (OAS1) is a ~46 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis. 1. Wickenhagen, A. et al. (2021) Science (New York, N.Y.) 374, eabj3624. PMID: 34581622 2. Magg, T. et al. (2021) Science immunology 6. PMID: 34145065 3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341 | ||||||||
| 注意事項 | For research use only. |
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