

| Каталожный номер | HF612014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-OAS1 Polyclonal Antibody (HF612014) is a rabbit polyclonal antibody detecting OAS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human OAS1 (Ser74-Pro165). | ||||||||
| Цель | E18/E16, (2-5')oligo(A) synthase 1, 2-5A synthase 1, 2'-5'-oligoadenylate synthase 1, OAS1, OIAS, p46/p42 OAS | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P00973 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | 2'-5'-oligoadenylate synthase 1 (OAS1) is a ~46 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis. 1. Wickenhagen, A. et al. (2021) Science (New York, N.Y.) 374, eabj3624. PMID: 34581622 2. Magg, T. et al. (2021) Science immunology 6. PMID: 34145065 3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341 | ||||||||
| Примечание | For research use only. |
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