Anti-OAS2 Polyclonal Antibody (HB125014)

Name: Anti-OAS2 Polyclonal Antibody
Brand: abinScience
SKU: HB125014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB125014

Description

Anti-OAS2 Polyclonal Antibody (HB125014) is a rabbit polyclonal antibody detecting OAS2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human OAS2 (Val11-His346).

Cible

p69 OAS / p71 OAS, OAS2, 2-5A synthase 2, p69OAS / p71OAS, 2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2

Purification

Purified by antigen affinity column.

Numéro d'accès

P29728

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

2'-5'-oligoadenylate synthase 2 (OAS2) is a ~82 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.

1. Sarkar, SN. et al. (1999) The Journal of biological chemistry 274, 25535-42. PMID: 10464285

2. Sarkar, SN. et al. (1999) The Journal of biological chemistry 274, 1848-55. PMID: 9880569

3. Hartmann, R. et al. (2001) FEBS letters 507, 54-8. PMID: 11682059

4. Kristiansen, H. et al. (2011) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 31, 41-7. PMID: 21142819

Note

For research use only.

Images

Reférences

Fiche technique

Anti-OAS2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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