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| カタログ番号 | HX222014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-OAZ1 Polyclonal Antibody (HX222014) is a rabbit polyclonal antibody detecting OAZ1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, and Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OAZ1 (Phe95-Glu219). | ||||||||
| ターゲット | OAZ1, OAZ, AZ1, Ornithine decarboxylase antizyme 1, ODC-Az | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P54368 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ornithine decarboxylase antizyme 1 (OAZ1) is a ~25 kDa protein. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. 1. Kanerva, K. et al. (2008) The Biochemical journal 409, 187-92. PMID: 17900240 2. Wu, HY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 11229-34. PMID: 26305948 3. Wu, D. et al. (2015) Scientific reports 5, 14738. PMID: 26443277 4. Lin, Y. et al. (2002) BMC cell biology 3, 15. PMID: 12097147 | ||||||||
| 注意事項 | For research use only. |
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