

| Каталожный номер | HX222014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-OAZ1 Polyclonal Antibody (HX222014) is a rabbit polyclonal antibody detecting OAZ1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, and Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human OAZ1 (Phe95-Glu219). | ||||||||
| Цель | OAZ1, OAZ, AZ1, Ornithine decarboxylase antizyme 1, ODC-Az | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P54368 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Ornithine decarboxylase antizyme 1 (OAZ1) is a ~25 kDa protein. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. 1. Kanerva, K. et al. (2008) The Biochemical journal 409, 187-92. PMID: 17900240 2. Wu, HY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 11229-34. PMID: 26305948 3. Wu, D. et al. (2015) Scientific reports 5, 14738. PMID: 26443277 4. Lin, Y. et al. (2002) BMC cell biology 3, 15. PMID: 12097147 | ||||||||
| Примечание | For research use only. |
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