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| カタログ番号 | HT271014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-OPA1 Polyclonal Antibody (HT271014) is a rabbit polyclonal antibody detecting OPA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OPA1 (Ser607-Lys960). | ||||||||
| ターゲット | KIAA0567, OPA1, Optic atrophy protein 1, Dynamin-like 120 kDa protein, mitochondrial | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60313 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dynamin-like GTPase OPA1, mitochondrial is a ~111 kDa protein. Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function. Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space. Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane. The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion. The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology. 1. Ishihara, N. et al. (2006) The EMBO journal 25, 2966-77. PMID: 16778770 2. Song, Z. et al. (2007) The Journal of cell biology 178, 749-55. PMID: 17709429 3. Ban, T. et al. (2010) Human molecular genetics 19, 2113-22. PMID: 20185555 4. Anand, R. et al. (2014) The Journal of cell biology 204, 919-29. PMID: 24616225 5. Ban, T. et al. (2017) Nature cell biology 19, 856-863. PMID: 28628083 6. Huang, G. et al. (2017) Cell reports 20, 923-934. PMID: 28746876 7. Ge, Y. et al. (2020) eLife 9. PMID: 31922487 8. Zhang, D. et al. (2020) eLife 9. PMID: 32228866 9. Stephan, T. et al. (2020) The EMBO journal 39, e104105. PMID: 32567732 10. Hu, C. et al. (2020) Cell death & disease 11, 940. PMID: 33130824 | ||||||||
| 注意事項 | For research use only. |
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