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| カタログ番号 | VK460014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ORF8/ns8 Polyclonal Antibody (VK460014) is a rabbit polyclonal antibody detecting ORF8 protein in ELISA, IHC, WB.
Highlights
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| 種反応性 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant SARS-CoV-2 ORF8/ns8 (Phe16-Ile121). | ||||||||
| ターゲット | ORF8 protein, ORF8, Non-structural protein 8, ns8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0DTC8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ORF8 protein (ns8) is a ~13 kDa protein. Plays a role in modulating the host immune response. May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors. Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway. May act by down-regulating major histocompability complex class I (MHC-I) at cell surface. May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58. 1. Chan, JF. et al. (2020) Lancet (London, England) 395, 514-523. PMID: 31986261 2. Wu, X. et al. (2022) mBio 13, e0040222. PMID: 35343786 3. Lin, X. et al. (2023) PLoS pathogens 19, e1011128. PMID: 36689483 4. Lin, X. et al. (2021) iScience 24, 102293. PMID: 33723527 5. Zhang, Y. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34021074 6. Matsuoka, K. et al. (2022) The Journal of biological chemistry 298, 101724. PMID: 35157849 7. Geng, H. et al. (2021) Frontiers in immunology 12, 679482. PMID: 34177923 | ||||||||
| 注意事項 | For research use only. |
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