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Anti-OTUB1 Polyclonal Antibody (HV049014)

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Aperçu
Numéro de catalogueHV049014
Description
Anti-OTUB1 Polyclonal Antibody (HV049014) is a rabbit polyclonal antibody detecting OTUB1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human OTUB1 (Met1-Lys271).
Cible OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1
Purification Purified by antigen affinity column.
Numéro d'accès Q96FW1
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy.

1. Borodovsky, A. et al. (2002) Chemistry & biology 9, 1149-59. PMID: 12401499
2. Balakirev, MY. et al. (2003) EMBO reports 4, 517-22. PMID: 12704427
3. Soares, L. et al. (2004) Nature immunology 5, 45-54. PMID: 14661020
4. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681
5. Stanišić, V. et al. (2009) The Journal of biological chemistry 284, 16135-16145. PMID: 19383985
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-OTUB1 Polyclonal Antibody

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