中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HV049014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-OTUB1 Polyclonal Antibody (HV049014) is a rabbit polyclonal antibody detecting OTUB1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OTUB1 (Met1-Lys271). | ||||||||
| ターゲット | OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96FW1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. 1. Borodovsky, A. et al. (2002) Chemistry & biology 9, 1149-59. PMID: 12401499 2. Balakirev, MY. et al. (2003) EMBO reports 4, 517-22. PMID: 12704427 3. Soares, L. et al. (2004) Nature immunology 5, 45-54. PMID: 14661020 4. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 5. Stanišić, V. et al. (2009) The Journal of biological chemistry 284, 16135-16145. PMID: 19383985 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
