

| Número de catálogo | HA837014 | ||||||||
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| Descripción |
Anti-OTUD3 Polyclonal Antibody (HA837014) is a rabbit polyclonal antibody detecting OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant human OTUD3 (Gly46-Lys220). | ||||||||
| Objetivo | OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q5T2D3, B1AZ99 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | OTU domain-containing protein 3 (OTUD3) is a ~45 kDa protein. Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Garshott, DM. et al. (2020) eLife 9. PMID: 32011234 3. Zhou, N. et al. (2022) Cell metabolism 34, 1023-1041.e8. PMID: 35675826 | ||||||||
| Nota | For research use only |
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