

| Numéro de catalogue | HA837014 | ||||||||
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| Description |
Anti-OTUD3 Polyclonal Antibody (HA837014) is a rabbit polyclonal antibody detecting OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant human OTUD3 (Gly46-Lys220). | ||||||||
| Cible | OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q5T2D3, B1AZ99 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | OTU domain-containing protein 3 (OTUD3) is a ~45 kDa protein. Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Garshott, DM. et al. (2020) eLife 9. PMID: 32011234 3. Zhou, N. et al. (2022) Cell metabolism 34, 1023-1041.e8. PMID: 35675826 | ||||||||
| Note | For research use only |
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