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| カタログ番号 | HA837014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-OTUD3 Polyclonal Antibody (HA837014) is a rabbit polyclonal antibody detecting OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human OTUD3 (Gly46-Lys220). | ||||||||
| ターゲット | OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5T2D3, B1AZ99 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | OTU domain-containing protein 3 (OTUD3) is a ~45 kDa protein. Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Garshott, DM. et al. (2020) eLife 9. PMID: 32011234 3. Zhou, N. et al. (2022) Cell metabolism 34, 1023-1041.e8. PMID: 35675826 | ||||||||
| 注意事項 | For research use only |
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