Anti-P2RX7 Polyclonal Antibody (HV713014)

Name: Anti-P2RX7 Polyclonal Antibody
Brand: abinScience
SKU: HV713014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV713014

Descripción

Anti-P2RX7 Polyclonal Antibody (HV713014) is a rabbit polyclonal antibody detecting P2RX7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human P2RX7 (Asp356-Tyr595).

Objetivo

P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor

Purificación

Purified by antigen affinity column.

Número de acceso

Q99572

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation. Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux. Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane. In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP.

1. Riedel, T. et al. (2007) Biophysical journal 93, 846-58. PMID: 17483156

2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740

3. Rassendren, F. et al. (1997) The Journal of biological chemistry 272, 5482-6. PMID: 9038151

4. Adinolfi, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 3393-404. PMID: 20453110

5. Pippel, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2156-E2165. PMID: 28235784

6. Markwardt, F. et al. (2024) PNAS nexus 3, pgae349. PMID: 39262850

7. Mou, YJ. et al. (2024) Biochemical and biophysical research communications 737, 150500. PMID: 39142135

8. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-P2RX7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

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