Anti-P2RX7 Polyclonal Antibody (HV713014)

Name: Anti-P2RX7 Polyclonal Antibody
Brand: abinScience
SKU: HV713014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV713014

Description

Anti-P2RX7 Polyclonal Antibody (HV713014) is a rabbit polyclonal antibody detecting P2RX7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human P2RX7 (Asp356-Tyr595).

Cible

P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor

Purification

Purified by antigen affinity column.

Numéro d'accès

Q99572

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation. Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux. Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane. In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP.

1. Riedel, T. et al. (2007) Biophysical journal 93, 846-58. PMID: 17483156

2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740

3. Rassendren, F. et al. (1997) The Journal of biological chemistry 272, 5482-6. PMID: 9038151

4. Adinolfi, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 3393-404. PMID: 20453110

5. Pippel, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2156-E2165. PMID: 28235784

6. Markwardt, F. et al. (2024) PNAS nexus 3, pgae349. PMID: 39262850

7. Mou, YJ. et al. (2024) Biochemical and biophysical research communications 737, 150500. PMID: 39142135

8. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061

Note

For research use only.

Images

Reférences

Fiche technique

Anti-P2RX7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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