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| カタログ番号 | MV713014 | ||||||||
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| 説明 |
Anti-P2RX7 Polyclonal Antibody (MV713014) is a rabbit polyclonal antibody detecting P2X purinoceptor 7; P2X7; ATP receptor; P2Z receptor; Purinergic receptor; P2rx7; P2x7 in ELISA, IHC, WB. Suitable for Rat and Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse P2RX7 (Gln52-Asp329). | ||||||||
| ターゲット | P2X purinoceptor 7; P2X7; ATP receptor; P2Z receptor; Purinergic receptor; P2rx7; P2x7 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Z1M0, Q64663 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel. Requires high millimolar-range concentrations of ATP to become activated. ATP binding trigers the rapid opening of the channel and allows Na(+) and Ca(2+) influx and K(+) efflux. Has also the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane. 1. Chessell, IP. et al. (1998) FEBS letters 439, 26-30. PMID: 9849870 2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740 3. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061 4. Di, A. et al. (2018) Immunity 49, 56-65.e4. PMID: 29958799 5. Yang, D. et al. (2015) Immunity 43, 923-32. PMID: 26572062 | ||||||||
| 注意事項 | For research use only |
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