

| Numéro de catalogue | HY517014 | ||||||||
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| Description |
Anti-P4HB Polyclonal Antibody (HY517014) is a rabbit polyclonal antibody detecting P4HB in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cricetulus griseus.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human P4HB (Phe216-Gly465). | ||||||||
| Cible | Protein disulfide-isomerase, Cellular thyroid hormone-binding protein, PDI, p55, ERBA2L, PO4DB, Prolyl 4-hydroxylase subunit beta, P4HB, PDIA1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P07237 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Protein disulfide-isomerase (P4HB) is a ~57 kDa protein. This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. 1. Yu, J. et al. (2020) The EMBO journal 39, e103841. PMID: 32149426 2. Bi, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 10650-5. PMID: 21670307 | ||||||||
| Note | For research use only. |
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