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Anti-PAFAH1B1 Polyclonal Antibody (HA642014)

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Vista general
Número de catálogoHA642014
Descripción
Anti-PAFAH1B1 Polyclonal Antibody (HA642014) is a rabbit polyclonal antibody detecting Platelet-activating factor acetylhydrolase IB subunit beta; Lissencephaly-1 protein; LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; PAFAH1B1; LIS1; MDCR; MDS; PAFAHA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Cat, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human PAFAH1B1 (Glu100-Arg410).
Objetivo Platelet-activating factor acetylhydrolase IB subunit beta; Lissencephaly-1 protein; LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; PAFAH1B1; LIS1; MDCR; MDS; PAFAHA
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P43034, P63005, P63004, B0LSW3, P43033, Q9PTR5, Q9GL51, Q90ZL4, Q7T394, Q803D2
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) is a ~46 kDa protein. Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner. Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.

1. Splinter, D. et al. (2012) Molecular biology of the cell 23, 4226-41. PMID: 22956769
Nota For research use only
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Formula
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Stock Solution
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Working Solution
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