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| カタログ番号 | HC597014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PAK2 Polyclonal Antibody (HC597014) is a rabbit polyclonal antibody detecting PAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PAK2 (Glu177-Ala419). | ||||||||
| ターゲット | S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13177 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein kinase PAK 2 (PAK2) is a ~58 kDa protein. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. 1. Jakobi, R. et al. (2003) The Journal of biological chemistry 278, 38675-85. PMID: 12853446 2. Vilas, GL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6542-7. PMID: 16617111 3. Mitsushima, M. et al. (2009) Molecular and cellular biology 29, 2816-27. PMID: 19273597 4. Hsu, RM. et al. (2010) Molecular biology of the cell 21, 287-301. PMID: 19923322 5. Antonarakis, SE. et al. (2021) Human molecular genetics 31, 1-9. PMID: 33693784 6. Martin, GA. et al. (1995) The EMBO journal 14, 1970-8. PMID: 7744004 7. Rudel, T. et al. (1997) Science (New York, N.Y.) 276, 1571-4. PMID: 9171063 | ||||||||
| 注意事項 | For research use only. |
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