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| カタログ番号 | HB610024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Pan AKT Polyclonal Antibody (HB610024) is a rabbit polyclonal antibody detecting Pan AKT in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| ターゲット | AKT1, EC:2.7.11.1, PKB, PKB alpha, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase, AKT2, EC:2.7.11.1, PKB beta, Protein kinase Akt-2, Protein kinase B beta, RAC protein kinase beta, RAC-PK-beta, RAC-beta serine/threonine-protein kinase, AKT3, EC:2.7.11.1, PKB gamma, PKBG, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, RAC-gamma serine/threonine-protein kinase, STK-2, Pan AKT | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31749, P31751, Q9Y243 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RAC-alpha serine/threonine-protein kinase (Pan-AKT,AKT1,AKT2,AKT3) is a ~55 kDa protein. AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. 1. Nicholson, KM. et al. (2002) Cellular signalling 14, 381-95. PMID: 11882383 2. Rönnstrand, L. (2004) Cellular and molecular life sciences : CMLS 61, 2535-48. PMID: 15526160 3. Cartlidge, RA. et al. (2005) The EMBO journal 24, 1696-705. PMID: 15861136 4. Heron-Milhavet, L. et al. (2011) Histology and histopathology 26, 651-62. PMID: 21432781 5. Hers, I. et al. (2011) Cellular signalling 23, 1515-27. PMID: 21620960 6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 7. Choppara, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 998-1003. PMID: 29343641 | ||||||||
| 注意事項 | For research use only |
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