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| カタログ番号 | HF535014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PARN Polyclonal Antibody (HF535014) is a rabbit polyclonal antibody detecting PARN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PARN (Lys178-Asp245). | ||||||||
| ターゲット | Deadenylating nuclease, Polyadenylate-specific ribonuclease, Poly(A)-specific ribonuclease PARN, Deadenylation nuclease, PARN, DAN | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95453 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Poly(A)-specific ribonuclease PARN is a ~73 kDa protein. 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. 1. Gao, M. et al. (2000) Molecular cell 5, 479-88. PMID: 10882133 2. Martînez, J. et al. (2001) The Journal of biological chemistry 276, 27923-9. PMID: 11359775 3. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 12748283 4. Gherzi, R. et al. (2004) Molecular cell 14, 571-83. PMID: 15175153 5. Körner, CG. et al. (1998) The EMBO journal 17, 5427-37. PMID: 9736620 6. Berndt, H. et al. (2012) RNA (New York, N.Y.) 18, 958-72. PMID: 22442037 7. Boele, J. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 11467-72. PMID: 25049417 | ||||||||
| 注意事項 | For research use only. |
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