Anti-PBLD Polyclonal Antibody (HA616014)

Name: Anti-PBLD Polyclonal Antibody
Brand: abinScience
SKU: HA616014
Price: 96 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug

Número:

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Referencias
Datasheet
SDS

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Número de catálogo

HA616014

Descripción

Anti-PBLD Polyclonal Antibody (HA616014) is a rabbit polyclonal antibody detecting Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP in ELISA, IHC, WB. Suitable for Human and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human PBLD (Met1-Ala288).

Objetivo

Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P30039, Q2HJF4

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Phenazine biosynthesis-like domain-containing protein (PBLD) is a ~31 kDa protein. Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signaling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication. Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection.

1. Zhu, H. et al. (2024) Cell death & disease 15, 727. PMID: 39362857

2. Chu, F. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2401174121. PMID: 39589880

3. Hou, P. et al. (2025) Nature communications 16, 496. PMID: 39779683

4. Li, DM. et al. (2013) World journal of gastroenterology 19, 2781-92. PMID: 23687415

Nota

For research use only

Imágenes

Western blot

Western blot analysis was performed using anti-PBLD polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate

Referencias

Datasheet

Anti-PBLD Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-PBLD Polyclonal Antibody (HA616014)

Vista general

Imágenes

Referencias

Datasheet

SDS