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| カタログ番号 | HA827014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PCGF3 Polyclonal Antibody (HA827014) is a rabbit polyclonal antibody detecting Polycomb group RING finger protein 3; RING finger protein 3A; PCGF3; RNF3; RNF3A in ELISA, IHC, WB. Suitable for Human, Bovine, and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human PCGF3 (Met1-Leu242). | ||||||||
| ターゲット | Polycomb group RING finger protein 3; RING finger protein 3A; PCGF3; RNF3; RNF3A | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q3KNV8, Q2KJ29, Q8BTQ0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Polycomb group RING finger protein 3 (PCGF3) is a ~28 kDa protein. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. 1. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332 | ||||||||
| 注意事項 | For research use only |
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