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Anti-PCK1 Polyclonal Antibody (HW538014)

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Vista general
Número de catálogoHW538014
Descripción
Anti-PCK1 Polyclonal Antibody (HW538014) is a rabbit polyclonal antibody detecting PCK1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human PCK1 (Asp311-Pro559).
Objetivo PCK1, PEPCK1, PEPCK-C, Serine-protein kinase PCK1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Purificación Purified by antigen affinity column.
Número de acceso P35558
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1) is a ~69 kDa protein. Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis.

1. Adams, DR. et al. (2014) Molecular genetics and metabolism 113, 161-70. PMID: 24863970
2. Santra, S. et al. (2016) Molecular genetics and metabolism 118, 21-7. PMID: 26971250
3. Vieira, P. et al. (2017) Molecular genetics and metabolism 120, 337-341. PMID: 28216384
4. Latorre-Muro, P. et al. (2018) Molecular cell 71, 718-732.e9. PMID: 30193097
5. Xu, D. et al. (2020) Nature 580, 530-535. PMID: 32322062
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PCK1 Polyclonal Antibody

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