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Anti-PCK1 Polyclonal Antibody (HW538014)

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Aperçu
Numéro de catalogueHW538014
Description
Anti-PCK1 Polyclonal Antibody (HW538014) is a rabbit polyclonal antibody detecting PCK1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human PCK1 (Asp311-Pro559).
Cible PCK1, PEPCK1, PEPCK-C, Serine-protein kinase PCK1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Purification Purified by antigen affinity column.
Numéro d'accès P35558
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1) is a ~69 kDa protein. Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis.

1. Adams, DR. et al. (2014) Molecular genetics and metabolism 113, 161-70. PMID: 24863970
2. Santra, S. et al. (2016) Molecular genetics and metabolism 118, 21-7. PMID: 26971250
3. Vieira, P. et al. (2017) Molecular genetics and metabolism 120, 337-341. PMID: 28216384
4. Latorre-Muro, P. et al. (2018) Molecular cell 71, 718-732.e9. PMID: 30193097
5. Xu, D. et al. (2020) Nature 580, 530-535. PMID: 32322062
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PCK1 Polyclonal Antibody

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