Anti-PDCD6IP Polyclonal Antibody (HV421014)

Name: Anti-PDCD6IP Polyclonal Antibody
Brand: abinScience
SKU: HV421014
Price: 96 USD
Availability: InStock

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Каталожный номер

HV421014

Описание

Anti-PDCD6IP Polyclonal Antibody (HV421014) is a rabbit polyclonal antibody detecting PDCD6IP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human PDCD6IP (Glu174-Ala383).

Цель

ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95, AIP1, ALIX, KIAA1375, PDCD6IP, Programmed cell death 6-interacting protein, PDCD6-interacting protein

Очистка

Purified by antigen affinity column.

Номер доступа

Q8WUM4

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Programmed cell death 6-interacting protein (PDCD6IP) is a ~96 kDa protein. Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.

1. Matsuo, H. et al. (2004) Science (New York, N.Y.) 303, 531-4. PMID: 14739459

2. Carlton, JG. et al. (2007) Science (New York, N.Y.) 316, 1908-12. PMID: 17556548

3. Morita, E. et al. (2007) The EMBO journal 26, 4215-27. PMID: 17853893

4. Carlton, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 10541-6. PMID: 18641129

5. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-PDCD6IP polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: K562 cell lysate
Lane 4: PC-12 cell lysate
Lane 5: Mouse liver lysate
Lane 6: Rat liver lysate

Ссылки

Даташит

Anti-PDCD6IP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Наборы для анализа

Anti-PDCD6IP Polyclonal Antibody (HV421014)

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