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| カタログ番号 | HC446014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PDE1C Polyclonal Antibody (HC446014) is a rabbit polyclonal antibody detecting PDE1C in ELISA, IHC, WB. Suitable for Mouse, Human, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PDE1C (Arg284-Asp630). | ||||||||
| ターゲット | PDE1C, Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C, 3', 5'-cyclic-GMP phosphodiesterase, 3', 5'-cyclic-AMP phosphodiesterase, Hcam3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14123 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C) is a ~80 kDa protein. Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). 1. Wang, L. et al. (2018) Human genetics 137, 437-446. PMID: 29860631 2. Loughney, K. et al. (1996) The Journal of biological chemistry 271, 796-806. PMID: 8557689 | ||||||||
| 注意事項 | For research use only. |
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