

| Каталожный номер | HC446014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-PDE1C Polyclonal Antibody (HC446014) is a rabbit polyclonal antibody detecting PDE1C in ELISA, IHC, WB. Suitable for Mouse, Human, and Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human PDE1C (Arg284-Asp630). | ||||||||
| Цель | PDE1C, Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C, 3', 5'-cyclic-GMP phosphodiesterase, 3', 5'-cyclic-AMP phosphodiesterase, Hcam3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q14123 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C) is a ~80 kDa protein. Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). 1. Wang, L. et al. (2018) Human genetics 137, 437-446. PMID: 29860631 2. Loughney, K. et al. (1996) The Journal of biological chemistry 271, 796-806. PMID: 8557689 | ||||||||
| Примечание | For research use only. |
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