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| カタログ番号 | HB133014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PDIA3 Polyclonal Antibody (HB133014) is a rabbit polyclonal antibody detecting PDIA3 in WB, IHC, ELISA. Suitable for Human, Mus musculus, Rattus norvegicus, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | WB, IHC, ELISA | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant PDIA3 (Asp162-Tyr416). | ||||||||
| ターゲット | PDIA3 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >90% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30101 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Protein disulfide-isomerase A3, EC:5.3.4.1, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, ER protein 57, ERp57, Endoplasmic reticulum resident protein 60, ER protein 60, ERp60, PDIA3 | ||||||||
| 背景 | Protein disulfide-isomerase A3 (PDIA3) is a ~56 kDa protein. Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. 1. Dick, TP. et al. (2002) Immunity 16, 87-98. PMID: 11825568 2. Peaper, DR. et al. (2005) The EMBO journal 24, 3613-23. PMID: 16193070 3. Gaucci, E. et al. (2016) Scientific reports 6, 37957. PMID: 27897272 4. Müller, IK. et al. (2022) Nature communications 13, 5383. PMID: 36104323 5. Bourdi, M. et al. (1995) Archives of biochemistry and biophysics 323, 397-403. PMID: 7487104 6. Domnick, A. et al. (2022) Nature communications 13, 4701. PMID: 35948544 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-PDIA3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: A375 cell lysate
Lane 3: LO2 cell lysate
Lane 4: U2OS cell lysate
Lane 5: Lncap cell lysate
Lane 6: K562 cell lysate
Lane 7: Jurkat cell lysate
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