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| カタログ番号 | HA712014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PDLIM4 Polyclonal Antibody (HA712014) is a rabbit polyclonal antibody detecting PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein; PDLIM4; RIL in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human PDLIM4 (Pro2-Glu84). | ||||||||
| ターゲット | PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein; PDLIM4; RIL | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P50479, P70271, P36202, Q3T005 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | PDZ and LIM domain protein 4 (PDLIM4) is a ~35 kDa protein. Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. 1. Zhang, Y. et al. (2009) The Journal of cell biology 184, 785-92. PMID: 19307596 2. Guryanova, OA. et al. (2011) The Journal of biological chemistry 286, 26849-59. PMID: 21636573 | ||||||||
| 注意事項 | For research use only |
Lane 1: A431 cell lysate
Lane 2: K562 cell lysate
Lane 3: Mouse brain lysate
Lane 4: Rat brain lysate
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