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Anti-PGAM5 Polyclonal Antibody (HB500014)

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Vista general
Número de catálogoHB500014
Descripción
Anti-PGAM5 Polyclonal Antibody (HB500014) is a rabbit polyclonal antibody detecting Serine/threonine-protein phosphatase PGAM5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human PGAM5 (Ala94-Ser289).
Objetivo Serine/threonine-protein phosphatase PGAM5, mitochondrial; 3.1.3.16; Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5; PGAM5
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q96HS1, Q8BX10, Q562B5
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Serine/threonine-protein phosphatase PGAM5, mitochondrial is a ~32 kDa protein. Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3.

1. Chen, G. et al. (2014) Molecular cell 54, 362-77. PMID: 24746696
2. Yu, B. et al. (2020) Nature communications 11, 2549. PMID: 32439975
3. Nag, S. et al. (2023) Cell reports 42, 112895. PMID: 37498743
4. Lo, SC. et al. (2008) Experimental cell research 314, 1789-803. PMID: 18387606
5. Wang, Z. et al. (2012) Cell 148, 228-43. PMID: 22265414
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PGAM5 Polyclonal Antibody

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