Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (P6.C12) (HT447013)

Name: Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (P6.C12)
Brand: abinScience
SKU: HT447013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT447013

Reactividad de especies

Human

Aplicaciones

IHC, IP, WB

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

P6.C12

Objetivo

High temperature requirement protein A2, OMI, HtrA2, PRSS25, Serine protease 25, Serine proteinase OMI, Serine protease HTRA2, mitochondrial, HTRA2, Omi stress-regulated endoprotease

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O43464

RRID

Anti-Phospho-HTRA2 (pS212) Antibody (P6.C12) (abinScience Cat# HT447013, RRID:AB_3725755)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Serine protease HTRA2, mitochondrial (pHTRA2) is a ~48 kDa protein. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis.

1. Savopoulos, JW. et al. (2000) Protein expression and purification 19, 227-34. PMID: 10873535

2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957

3. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104

4. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105

5. Balakrishnan, MP. et al. (2009) American journal of physiology. Heart and circulatory physiology 297, H643-53. PMID: 19502560

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Phospho-HTRA2 (pS212) Antibody (P6.C12)

Referencias

Datasheet

Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (P6.C12).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo