Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (SAA0299) (HT447023)

Name: Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (SAA0299)
Brand: abinScience
SKU: HT447023
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HT447023

Reactivité des espèces

Human

Applications

IHC, IP, WB

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA0299

Cible

High temperature requirement protein A2, OMI, HtrA2, PRSS25, Serine protease 25, Serine proteinase OMI, Serine protease HTRA2, mitochondrial, HTRA2, Omi stress-regulated endoprotease

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

O43464

RRID

Anti-Phospho-HTRA2 (pS212) Antibody (SAA0299) (abinScience Cat# HT447023, RRID:AB_3725756)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Serine protease HTRA2, mitochondrial (pHTRA2) is a ~48 kDa protein. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis.

1. Savopoulos, JW. et al. (2000) Protein expression and purification 19, 227-34. PMID: 10873535

2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957

3. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104

4. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105

5. Balakrishnan, MP. et al. (2009) American journal of physiology. Heart and circulatory physiology 297, H643-53. PMID: 19502560

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Phospho-HTRA2 (pS212) Antibody (SAA0299)

Reférences

Fiche technique

Anti-Phospho-HTRA2 (pS212) Recombinant Antibody (SAA0299).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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