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| カタログ番号 | RC581013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Rat | ||||
| アプリケーション | IHC, IP, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | L83/11R | ||||
| ターゲット | h-DRK1, Delayed rectifier potassium channel 1, Potassium voltage-gated channel subfamily B member 1, KCNB1, Voltage-gated potassium channel subunit Kv2.1, DRK1 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P15387 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Potassium voltage-gated channel subfamily B member 1 (p-KCNB1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. 1. Murakoshi, H. et al. (1999) The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 1728-35. PMID: 10024359 2. Du, J. et al. (2000) The Journal of physiology 522 Pt 1, 19-31. PMID: 10618149 3. Malin, SA. et al. (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 10094-105. PMID: 12451110 4. Guan, D. et al. (2007) The Journal of physiology 581, 941-60. PMID: 17379638 5. Mohapatra, DP. et al. (2009) Channels (Austin, Tex.) 3, 46-56. PMID: 19276663 6. Guan, D. et al. (2013) The Journal of physiology 591, 4807-25. PMID: 23878373 7. Feinshreiber, L. et al. (2010) Journal of cell science 123, 1940-7. PMID: 20484665 8. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340 9. Taglialatela, M. et al. (1991) Molecular pharmacology 40, 299-307. PMID: 1875913 10. VanDongen, AM. et al. (1990) Neuron 5, 433-43. PMID: 2206531 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Phospho-KCNB1 (pS563) Antibody (L83/11R)
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