Anti-Phospho-p53 (pT18) Recombinant Antibody (23#) (HY039013)

Name: Anti-Phospho-p53 (pT18) Recombinant Antibody (23#)
Brand: abinScience
SKU: HY039013
Price: 191 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY039013

Reactivité des espèces

Human

Applications

IHC, IP, WB

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

23#

Cible

Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P04637

RRID

Anti-Phospho-p53 (pT18) Antibody (23#) (abinScience Cat# HY039013, RRID:AB_3725760)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Cellular tumor antigen p53 (p-TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664

2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540

3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724

4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775

5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061

6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671

7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958

8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538

9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990

10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Phospho-p53 (pT18) Antibody (23#)

Reférences

Fiche technique

Anti-Phospho-p53 (pT18) Recombinant Antibody (23#).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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