Anti-PIK3C3 Polyclonal Antibody (HV616014)

Name: Anti-PIK3C3 Polyclonal Antibody
Brand: abinScience
SKU: HV616014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV616014

Description

Anti-PIK3C3 Polyclonal Antibody (HV616014) is a rabbit polyclonal antibody detecting PIK3C3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pig, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PIK3C3 (Tyr631-Trp885).

Cible

PtdIns-3-kinase type 3, Phosphatidylinositol 3-kinase p100 subunit, hVps34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, PI3-kinase type 3, VPS34, PI3K type 3, PIK3C3

Purification

Purified by antigen affinity column.

Numéro d'accès

Q8NEB9

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) is a ~101 kDa protein. Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.

1. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358

2. Chen, YH. et al. (2021) Nature communications 12, 1322. PMID: 33637724

3. Volinia, S. et al. (1995) The EMBO journal 14, 3339-48. PMID: 7628435

4. Zhang, BC. et al. (2020) Nature immunology 21, 868-879. PMID: 32690950

5. Sagona, AP. et al. (2010) Nature cell biology 12, 362-71. PMID: 20208530

6. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123

Note

For research use only.

Images

Reférences

Fiche technique

Anti-PIK3C3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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