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| カタログ番号 | HV616014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PIK3C3 Polyclonal Antibody (HV616014) is a rabbit polyclonal antibody detecting PIK3C3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pig, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIK3C3 (Tyr631-Trp885). | ||||||||
| ターゲット | PtdIns-3-kinase type 3, Phosphatidylinositol 3-kinase p100 subunit, hVps34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, PI3-kinase type 3, VPS34, PI3K type 3, PIK3C3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8NEB9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) is a ~101 kDa protein. Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. 1. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358 2. Chen, YH. et al. (2021) Nature communications 12, 1322. PMID: 33637724 3. Volinia, S. et al. (1995) The EMBO journal 14, 3339-48. PMID: 7628435 4. Zhang, BC. et al. (2020) Nature immunology 21, 868-879. PMID: 32690950 5. Sagona, AP. et al. (2010) Nature cell biology 12, 362-71. PMID: 20208530 6. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123 | ||||||||
| 注意事項 | For research use only. |
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