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| カタログ番号 | HB055014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PIK3R1/PI3-kinase p85-alpha Polyclonal Antibody (HB055014) is a rabbit polyclonal antibody detecting PI3-kinase subunit p85-alpha in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIK3R1/PI3-kinase p85-alpha (Trp624-Val718). | ||||||||
| ターゲット | PI3-kinase subunit p85-alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, GRB1, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1, PI3-kinase regulatory subunit alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P27986 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1/PI3-kinase p85-alpha) is a ~83 kDa protein. Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. 1. Miled, N. et al. (2007) Science (New York, N.Y.) 317, 239-42. PMID: 17626883 2. Mandelker, D. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16996-7001. PMID: 19805105 3. Vainikka, S. et al. (1994) The Journal of biological chemistry 269, 18320-6. PMID: 7518429 4. Winnay, JN. et al. (2010) Nature medicine 16, 438-45. PMID: 20348923 | ||||||||
| 注意事項 | For research use only. |
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