

| Каталожный номер | VK015014 | ||||||||
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| Описание |
Anti-PIV5 P/V Polyclonal Antibody (VK015014) is a rabbit polyclonal antibody detecting P/V in WB, IHC, ELISA.
Highlights
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| Реактивность видов | Parainfluenza virus 5 (PIV5) | ||||||||
| Применения | WB,IHC,ELISA | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant PIV5 P/V (Met1-Thr222). | ||||||||
| Цель | P/V | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >90% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P11207 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Альтернативные названия | Non-structural protein V, P/V | ||||||||
| Фон | Non-structural protein V is a ~23 kDa protein. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Efficiently blocks type I IFN signaling following infection by behaving as a substrate receptor for CUL4-DDB1 E3 ligase complex and targeting host STAT1 for proteasomal degradation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway. | ||||||||
| Примечание | For research use only. |
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