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| カタログ番号 | HS811014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PKN1 Polyclonal Antibody (HS811014) is a rabbit polyclonal antibody detecting PKN1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PKN1 (Ser608-Gln871). | ||||||||
| ターゲット | Protein kinase C-like PKN, Serine/threonine-protein kinase N1, PRK1, Serine-threonine protein kinase N, PKN, Protease-activated kinase 1, PRKCL1, PKN1, Protein-kinase C-related kinase 1, PAK-1, Protein kinase PKN-alpha, PAK1, Protein kinase C-like 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q16512 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein kinase N1 (PKN1) is a ~103 kDa protein. PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-PKN1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MDA-MB-231 cell lysate
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