

| Каталожный номер | HS844014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-PKN2 Polyclonal Antibody (HS844014) is a rabbit polyclonal antibody detecting PKN2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human PKN2 (Glu67-Ile312). | ||||||||
| Цель | PRK2, PKN gamma, PRKCL2, Protein kinase C-like 2, Serine/threonine-protein kinase N2, PKN2, Protein-kinase C-related kinase 2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q16513 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Serine/threonine-protein kinase N2 (PKN2) is a ~112 kDa protein. PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. 1. Guen, VJ. et al. (2016) Cell cycle (Georgetown, Tex.) 15, 678-88. PMID: 27104747 | ||||||||
| Примечание | For research use only. |
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