Anti-PKP1 Polyclonal Antibody (HC672014)

Name: Anti-PKP1 Polyclonal Antibody
Brand: abinScience
SKU: HC672014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HC672014

Description

Anti-PKP1 Polyclonal Antibody (HC672014) is a rabbit polyclonal antibody detecting PKP1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PKP1 (Asn500-Asn742).

Cible

B6P, Plakophilin-1, Band 6 protein, PKP1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13835

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Plakophilin-1 (PKP1) is a ~82 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments. Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG. Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions. Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes.

1. Wolf, A. et al. (2013) Journal of cell science 126, 1832-44. PMID: 23444369

2. Hofmann, I. et al. (2000) Journal of cell science 113 ( Pt 13), 2471-83. PMID: 10852826

3. Uttagomol, J. et al. (2019) International journal of molecular sciences 20. PMID: 31835537

4. McGrath, JA. et al. (1997) Nature genetics 17, 240-4. PMID: 9326952

5. Sobolik-Delmaire, T. et al. (2010) The Journal of investigative dermatology 130, 2638-46. PMID: 20613778

6. Wolf, A. et al. (2010) The Journal of cell biology 188, 463-71. PMID: 20156963

7. Fischer-Kešo, R. et al. (2014) Molecular and cellular biology 34, 4244-56. PMID: 25225333

Note

For research use only.

Images

Reférences

Fiche technique

Anti-PKP1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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