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| カタログ番号 | HC672014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PKP1 Polyclonal Antibody (HC672014) is a rabbit polyclonal antibody detecting PKP1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PKP1 (Asn500-Asn742). | ||||||||
| ターゲット | B6P, Plakophilin-1, Band 6 protein, PKP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13835 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Plakophilin-1 (PKP1) is a ~82 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments. Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG. Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions. Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes. 1. Wolf, A. et al. (2013) Journal of cell science 126, 1832-44. PMID: 23444369 2. Hofmann, I. et al. (2000) Journal of cell science 113 ( Pt 13), 2471-83. PMID: 10852826 3. Uttagomol, J. et al. (2019) International journal of molecular sciences 20. PMID: 31835537 4. McGrath, JA. et al. (1997) Nature genetics 17, 240-4. PMID: 9326952 5. Sobolik-Delmaire, T. et al. (2010) The Journal of investigative dermatology 130, 2638-46. PMID: 20613778 6. Wolf, A. et al. (2010) The Journal of cell biology 188, 463-71. PMID: 20156963 7. Fischer-Kešo, R. et al. (2014) Molecular and cellular biology 34, 4244-56. PMID: 25225333 | ||||||||
| 注意事項 | For research use only. |
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