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| カタログ番号 | HT140014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PLA2G6 (Asp484-Val701). | ||||||||
| ターゲット | Patatin-like phospholipase domain-containing protein 9, Group VI phospholipase A2, iPLA2-beta, PLA2G6, PLPLA9, Intracellular membrane-associated calcium-independent phospholipase A2 beta, GVI PLA2, CaI-PLA2, Palmitoyl-CoA hydrolase, 2-lysophosphatidylcholine acylhydrolase, 85/88 kDa calcium-independent phospholipase A2, PNPLA9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60733 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 85/88 kDa calcium-independent phospholipase A2 (PLA2G6) is a ~89 kDa protein. Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles. Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content. 1. Ma, Z. et al. (1999) The Journal of biological chemistry 274, 9607-16. PMID: 10092647 2. Larsson Forsell, PK. et al. (1999) European journal of biochemistry 262, 575-85. PMID: 10336645 3. Engel, LA. et al. (2010) PloS one 5, e12897. PMID: 20886109 4. Larsson, PK. et al. (1998) The Journal of biological chemistry 273, 207-14. PMID: 9417066 5. Hsu, YH. et al. (2013) PloS one 8, e59267. PMID: 23533611 | ||||||||
| 注意事項 | For research use only. |
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