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| カタログ番号 | HV798014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PLAA Polyclonal Antibody (HV798014) is a rabbit polyclonal antibody detecting PLAA in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PLAA (Glu162-Ala312). | ||||||||
| ターゲット | PLAP, PLA2P, Phospholipase A-2-activating protein, PLAA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y263 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipase A-2-activating protein (PLAA) is a ~87 kDa protein. Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. 1. Papadopoulos, C. et al. (2017) The EMBO journal 36, 135-150. PMID: 27753622 2. Zhang, F. et al. (2008) Cellular signalling 20, 844-61. PMID: 18291623 3. Falik Zaccai, TC. et al. (2017) Brain : a journal of neurology 140, 370-386. PMID: 28007986 | ||||||||
| 注意事項 | For research use only. |
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